Differences in patient characteristics and cardiac arrhythmias in adults with benign vs. malignant neoplasm of the heart; an analysis from the 2016–2020 national inpatient sample.
No Thumbnail Available
Authors
Aggarwal, Shruti
Issue Date
2024
Type
Article
Language
en
Keywords
cardiac neoplasms , cardiac arrhythmias
Alternative Title
Abstract
Introduction: While cardiac neoplasms can disrupt conduction pathways, events of arrhythmias among patients with benign neoplasm of the heart (BNH) and malignant neoplasm of the heart (MNH) are not well reported. We aim to assess patient characteristics and odds of cardiac arrhythmias between BNH and MNH.
Methods: Records of adults with BNH or MNH were extracted from the 2016-2020 National Inpatient Sample using relevant ICD-10 codes. Differences in various characteristics, presence of cardiac arrhythmias and outcomes were explored.
Results: 23,450 patients diagnosed with a cardiac neoplasm were included. 21,200 (90.4%) had a recorded diagnosis of BNH, while 2,250 (9.6%) had a diagnosis for MNH. BNH cases were older (65.07 vs 52.15, p<0.01), consisted mostly of patients of female sex (63.5% BNH vs 48.2% MNH, p<0.01) and were more comorbid, with significantly higher proportion of patients with cirrhosis, diabetes, hypertension, peripheral vascular disease, smoking, obesity, chronic kidney disease, alcohol abuse, drug abuse, and lipid disorder compared to those with MNH (all p=<0.001). While the major ity of BNH cases were covered by Medicare, Private insurance forms were mostly used by MNH patients. Despite BNH having higher proportions of comorbidities, a higher mean Charlson Comorbidity Index (CCI) score was notedamong the MNH cohort. (2.71 BNH vs 5.23 MNH, p<0.01) After adjusting for confounding factors, BNH patients had higher odds of reporting ventricular tachycardia (aOR 1.58 95% CI 1.17–2.14, p=0.003), while showing reduced odds of events for atrial flutter (aOR 0.51 95% CI 0.44-0.61, p<0.001). The BNH cohort also had reduced odds of adverse outcomes of cardiogenic shock (aOR 0.377, 95% CI 0.306-0.466, p<0.001), acute kidney injury (AKI) (aOR 0.629, 95% CI 0.553-0.716, p<0.001), and death (aOR 0.200, 95% CI 0.166-0.241, p<0.001) than those with MNH (table 1).
Conclusion: While patients with BNH were older and had higher a proportion of comorbidities, they reported reduced odds of atrial flutter and better overall outcomes, but higher odds of ventricular tachycardia.
Description
Citation
Dhaliwal, J.S., Karalis, I., Carver, C. et al. (2024) 128 Differences in patient characteristics and cardiac arrhythmias in adults with benign vs. malignant neoplasm of the heart; an analysis from the 2016–2020 national inpatient sample. Heart; 110 (supp_3) : A133-A134.
Publisher
License
Journal
Heart
Volume
Issue
PubMed ID
ISSN
1468-201X