A review of malignant pleural mesothelioma in a large North East UK pleural centre.
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Authors
Murphy, Declan
Mount, Alexander
Starkie, Fiona
Taylor, Leah
Aujayeb, Avinash
Issue Date
2021
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Abstract
"Objectives: The National Mesothelioma Audit 2020 showed Northumbria to have low rates of histopathological confirmation, treatment and one-year survival rates for malignant pleural mesothelioma (MPM). We hypothesized that an internal analysis over a 10-year period provides valuable insights into presentation, diagnosis, treatment and outcomes.
Methods: A single-centre retrospective case series of all confirmed MPM patients between 1 January 2009 and 31 December 2019 was performed. Demographics, clinical, radiological and histopathological characteristics and outcomes were collected. Statistical analysis was performed using SPSS V26.0.
Results: A total of 247 patients had MPM. About 86% were male, mean age 75.7 years. Dyspnoea (77.4%) and chest pain (38.5%) were commonest symptoms. 64.9 and 71.4% had pleural thickening and effusion, respectively. About 86.8% had at least one attempt to obtain a tissue biopsy, but histopathological confirmation in only 108 (43.7%). About 66.3% with PS 0 and 1 (62.7% of total cohort) had at least one anti-cancer therapy. Death within 12 months was associated with disease progression within 6 months (p?0.001). Chemotherapy (p?0.001) and epithelioid histological subtype (p=0.01) were protective.
Conclusions: This study confirms known epidemiology of MPM, demonstrates variability in practices and highlights how some NMA recommendations are not met. This provides the incentive for a regional mesothelioma multi-disciplinary meeting."
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Citation
Murphy, D., Mount, A., Starkie, F., et al. (2021) A review of malignant pleural mesothelioma in a large North East UK pleural centre. Pleura and Peritoneum; 6 (1) : 13-19.
Publisher
Pleura and Peritoneum
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2364-768X