The Prevalence And Outcomes Of Depression In Older HIV-Positive Adults In Northern Tanzania: A Longitudinal Study.
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Authors
Dotchin, Catherine
Gray, William K.
Walker, Richard
Issue Date
2022
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Abstract
"Background: Studies of depression and its outcomes in older people living with HIV (PLWH) are currently lacking in sub-Saharan Africa.
Objectives: To investigate prevalence of psychiatric disorders in PLWH aged ?50 years in Tanzania focussing on prevalence and two-year outcomes of depression.
Method: PLWH aged ?50 were systematically recruited from an outpatient clinic and assessed using the Mini-International Neuropsychiatric interview (MINI). Neurological and functional impairment were assessed at year two follow-up.
Results: At baseline, 253 PLWH were recruited (72.3% female, median age 57, 95.5% on cART). DSM-IV depression was highly prevalent (20.9%), whereas other DSM-IV psychiatric disorders were uncommon. At follow-up (n=162) DSM-IV depression non-significantly decreased (14.2% -11.1%) ?2:2.48 p=0.29). Baseline depression, was associated with increased functional (p=0.018), and neurological impairment (p<0.001) and negative life events (p=0.001) at follow-up, but HIV and sociodemographic factors were not.
Conclusions: In this setting, depression appears highly prevalent and associated with poorer outcomes. This may be a future intervention target. "
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Citation
Dua, D., Stubbs, O., Urasa, S. et al. (2022) The Prevalence And Outcomes Of Depression In Older HIV-Positive Adults In Northern Tanzania: A Longitudinal Study. PREPRINT (Version 1) available at Research Square.
Publisher
Research Square