Diagnostic accuracy of the T-MACS decision aid with a contemporary point-of-care troponin assay.
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Authors
Harrison, Mark
Issue Date
2019
Type
Article
Language
en
Keywords
clinical decision-making , diagnostics , cardiac troponin (cTn)
Alternative Title
Abstract
Objectives: The rapid turnaround time of point-of-care (POC) cardiac troponin (cTn) assays is highly attractive for crowded emergency departments (EDs). We evaluated the diagnostic accuracy of the Troponin-only Manchester Acute Coronary Syndromes (T-MACS) decision aid with a POC cTn assay.
Methods: In a prospective diagnostic accuracy study at eight EDs, we included patients with suspected acute coronary syndromes (ACS). Blood drawn on arrival and 3?hours later was analysed for POC cTnI (i-Stat, Abbott Point of Care). The primary outcome was a diagnosis of ACS, which included both an adjudicated diagnosis of acute myocardial infarction (AMI) based on serial laboratory cTn testing and major adverse cardiac events (death, AMI or coronary revascularisation) within 30 days.
Results: Of 716 patients included, 105 (14.7%) had ACS. Using serial POC cTnI concentrations over 3?hours could have 'ruled out' ACS in 198 (31.2%) patients with a sensitivity of 99.0% (95% CI 94.4% to 100.0%) and negative predictive value 99.5% (95% CI 96.5% to 99.9%). No AMIs were missed. T-MACS 'ruled in' ACS for 65 (10.4%) patients with a positive predictive value of 91.2% (95% CI 82.1% to 95.9%) and specificity 98.9% (97.6% to 99.6%).
Conclusion: With a POC cTnI assay, T-MACS could 'rule out' ACS for approximately one-third of patients within 3hours while 'ruling in' ACS for another 10%. The rapid turnaround time and portability of the POC assay make this an attractive pathway for use in crowded EDs or urgent care centres. Future work should also evaluate use in the prehospital environment.
Description
Citation
Body, R., Almashali, M., Morris, N. et al. (2019) Diagnostic accuracy of the T-MACS decision aid with a contemporary point-of-care troponin assay. Heart; 105 (10) : 768-774.
Publisher
License
Journal
Heart
Volume
Issue
ISSN
1468-201X